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監控人類細胞移植用途的抗體
(Antibodies for Detecting Human Cells Transplanted into Mice and Rats)

STEM101、STEM121、STEM123是三種小鼠來源的單克隆抗體，用于人類細胞向小鼠和大鼠移植實驗中，監控細胞移植、轉移、分化。

■ 產品特點

· STEM101 reacts specifically with the nuclear human Ku80 protein; the antibody does not cross-react with mouse
   or rat Ku80 in brain tissue or cell extracts
· STEM121 reacts with a human cytoplasmic protein expressed in brain, liver, pancreas, and CNS cells
   the antibody does not cross-react with brain tissue or cell extracts from mouse, rat, or cynomologous monkey
· STEM123 reacts specifically with human GFAP, a marker of astroglial cells; the antibody does not cross-react
   with brain tissue or cell extracts from mouse or rat

■ 產品應用

· Localization, quantification, and/or characterization of engrafted cells of human origin by immunohistochemistry
and immunofluorescence

Code No.	Product	Size
Y40400	STEM101^®	50 μg
Y40410	STEM121^®	50 μg
Y40420	STEM123^®	50 μg

■ 產品詳情

STEM101 detects nuclei of transplanted human neural stem cells in the olfactory bulb of a mouse brain.

STEM121 detects migration and differentiation of transplanted human neural stem cells in the hippocampus of a mouse brain.

STEM123 detects human GFAP+ astrocytes differentiated from human neural stem cells after transplantation into a mouse brain.

參考文獻：

1. Cummings BJ, et al. (2005) Human neural stem cells differentiate and promote locomotor recovery in spinal
    cord-injured mice. PNAS 102: 14069-14074.
2. Guzman R, et al. (2007) Long-term monitoring of transplanted human neural stem cells in developmental and
    pathological contexts with MRI. PNAS 104: 10211-10216.
3. Tamaki SJ, et al. (2009) Neuroprotection of Host Cells by Human Central Nervous System Stem Cells in a Mouse
    Model of Infantile Neuronal Ceroid Lipofuscinosis. Cell Stem Cell 5:310-319.
4. Salazar DL, et al. (2010) Human Neural Stem Cells Differentiate and Promote Locomotor Recovery in an Early
    Chronic Spinal Cord Injury NOD-scid Mouse Model. PLoS ONE 5: e12272.
5. Kelly S, et al. Transplanted human fetal neural stem cells survive, migrate, and differentiate in ischemic rat

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